GABA is an inhibitory (calming) neurotransmitter in the brain. It functions to mitigate over-excitation in neurons and is reduced in times of stress. While it was once believed that GABA could not permeate the blood-brain barrier and was thus void of psychoactive effects, recent research indicates that GABA supplementation can indirectly solicit GABAergic effects in the brain. [1]


In two studies, GABA supplementation - either alone or in the form of GABA-enriched rice -  was shown to prevent increases in the stress hormone cortisol and alleviate perceived stress. [2] [3]


Multiple studies have elucidated the beneficial effects of GABA supplementation on sleep, both when used alone and in combination with L-theanine, as found in our formula. Subjects taking GABA reported being more refreshed upon waking alongside improved sleep quality. [2] [3] [4]


*Research discussed herein represent preliminary findings requiring additional and more rigorous evaluation before certain health claims can be made.


[1] Hepsomali, Piril, et al. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.” Frontiers, Frontiers, 10 Aug. 2020,

[2] Yamatsu, Atsushi, and Et Al. “Beneficial Action of GABA on Sleep and Frequent Night Urination in the Elderly.” 薬理と治療, ライフサイエンス出版, 1 Jan. 2013,


[3] S, Yoshida. “ Optimization of a γ-Aminobutyric Acid (GABA) Enrichment Process for Hokkaido White Rice and the Effects of GABA-Enriched White Rice on Stress Relief in Humans.” Restricted Content, Accessed 14 Nov. 2023.

[4] Kim, Suhyeon, et al. “GABA and L-Theanine Mixture Decreases Sleep Latency and Improves NREM Sleep.” Pharmaceutical Biology, U.S. National Library of Medicine, Dec. 2019,





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